- Spin doctors
- Spineshank
- Spinnerette
- Spiritual Front
- Spiritualized
- Spitfire
- Spoken
- Spoon
- Spor
- SPYAIR
- Squeeze
- Squirrel Nut Zippers
- SR-71
- ST
- St. Vincent
- ST1M
- Stabbing Westward
- Stacey Kent
- Stacie Orrico
- Stahlmann
- Staind
- Stakka Bo
- Stalker
- Stan Ridgway
- Stanley Brothers
- Stanley Clarke
- Starflyer 59
- Starfucker
- Starsailor
- Starship
- State
- Stateless
- Static X
- Status Quo
- Stealers Wheel
- Steel Panther
- Steel Pulse
- Steel Train
- Steeleye Span
- Steelheart
- Steely Dan
- Stefanie Heinzmann
- Stemm
- Stephen Marley
- Stephen Stills
- Steppenwolf
- Steps
- Stereo Mcs
- Stereo Total
- Stereolab